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It typically resolves within two to four weeks as your system adapts

Moreover, in a model of immune tolerance induced by LPS in volunteers, -glucan can partially reverse LPS-induced immune tolerance by modulating the cellular epigenome, which allows elevated expression of H3K27ac, thereby restoring the ability of M to produce pro-inflammatory cytokines (197)

Taking curcumin with fat, phospholipids, or in lipid-processed nutraceutical forms may also enhance its bioavailability

Each method has its pros and cons, so its essential to discuss it with a healthcare professional to determine which option is best suited for your needs