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For roughly 30% of depression patients, it is not

The aforementioned meta-analysis of 31 RCTs identified the following hGH side effects and their incidence [19]: Swelling in the limbs: 50% Insulin resistance: 22% Joint discomfort: 21% Carpal tunnel syndrome: 19% Most of these symptoms were related to temporary water retention and progressively decreased as participants adapted to the treatment [23]

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Sensitivity analyses included a mixed-effects model for repeated measures and exclusion of post-baseline data from non-adherent participants to confirm robustness

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