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Overall its been messy, and Im not entirely sure what microdosing really means to people, said Alexandra Sowa, MD, a dual board-certified obesity and internal medicine physician and clinical instructor at the NYU Grossman School of Medicine

KD appears well positioned to intervene in this process, overlapping with broader microbiota-targeted strategiesincluding probiotics, synbiotics, FMT, and antibioticsthat are increasingly regarded as potential disease-modifying interventions in PD [129, 177]

Similarly, targeting the central ferroptosis inhibitor SLC7A11, the expression of which is upregulated via the MISP/MST/yes-associated protein signaling pathway, represents a rational strategy to sensitize cells to ferroptosis (109)

While early demand for the oral version has been encouraging, it has yet to offset broader portfolio softness