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The cellular anti-inflammatory action of the nanosheets is achieved by scavenging intracellular ROS of M1 macrophages and promoting their transition to M2 phenotype, which largely prevents mBMSC apoptosis, while the Zn 2+ released from the degrading nanosheets upregulates the ALP level of mBMSCs, facilitating osteogenic differentiation and biomineralization

But taking it on an empty stomach might help it absorb better