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Key laboratory markers include: IGF-1: Primary marker for sermorelin effectiveness and GH status Total and free testosterone: Evaluates TRT dosing adequacy Estradiol (E2): Monitors testosterone-to-estrogen conversion SHBG (sex hormone-binding globulin): Assesses bioavailable testosterone CBC/hematocrit: Monitors for TRT-related polycythemia PSA: Prostate screening for men on TRT Comprehensive metabolic panel: Liver function, kidney function, glucose metabolism Lipid panel: Cholesterol and triglyceride monitoring Hemoglobin A1c: Long-term glucose control assessment Labs are typically drawn at baseline, 6-8 weeks after initiation, and then every 3-6 months

Most side effects occur during the early weeks of treatment and reduce significantly over time

Once the trigger is corrected for example, rapid weight loss slows down, calorie intake improves, or deficiencies are treated the hair cycle often begins to normalise