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Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes

In a phase 2 trial of obese subjects, cagrilintide used in different subcutaneous doses once weekly was associated with a mean weight loss of 6-10.8% after 26 weeks, compared with 9.0% with the glucagon-like 1 receptor (GLP-1R) liraglutide (3 mg/d) and 3% with placebo at 26 weeks

In these cases, a change in lipid peroxidation was found to occur simultaneously with an inverse change in the activity of antioxidant enzymes ( Reference Liang, Liu and Xu 23 , Reference Wang, Li and Lu 32 , Reference Hirano, Hamajima and Horiuchi 34 )