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One key process is glutamate excitotoxicity, where a buildup of glutamate at the synapse due to reduced function of the transporter EAAT2 (also known as GLT-1) leads to overstimulation of N-methyl-D-aspartate (NMDA) receptors

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For the cells incubated for 6 h, a similar observation to the 2 h group was found

Aged female NMRI mice (12-month-old) that received a diet with the ligustroside (50 mg/kg, 6.25 mg/kg body weight) for a period of 6 months showed an improvement in spatial working memory as compared to aged-control untreated mice

doi: 10.1007/s00204-004-0557-0