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Spiekerkoetter U, et al

HA fillers are ideal for addressing: Cheeks Under-eye hollows Nasolabial folds Marionette lines Results are visible immediately and typically last between 6 to 18 months, depending on the product used and the area treated

27-34 Of note, several trials in the PIONEER program used two estimands to further distinguish their analyses: 1) a treatment-policy estimand, which used data collected at the end of the study period (e.g., week 26 or 52) in the analysis regardless of treatment discontinuation or use of rescue medication

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