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Interestingly, as the authors note, skeletal muscle does not appear to express a functional GLP-1 receptor

These include a noticeable reduction in hunger within the first week or two, decreased cravings for high-calorie foods, ability to eat smaller portions without hunger compensation, and consistent weekly weight loss of 12 pounds over a 48 week period

Tirzepatide's dual-pathway activation makes it particularly effective for patients with specific genetic profiles, identified through the PlexusDx Precision Peptide Genetic Test, that show reduced sensitivity to GLP-1 signaling alone

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