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Type 2 diabetes (34.80%) and weight loss (14.71%) emerged as the most predominant indications, while others accounted for 3.92%, and unknown or missing constituted 46.57% (Table 1)

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The agency's language was unambiguous: "Retatrutide and Cagrilintide cannot be used in compounding under federal law." [3,5] The letters cited multiple FDCA violations, including Section 505(a) (unapproved new drug), Section 502(f)(1) (inadequate directions for use), and Sections 301(a) and 301(d) (introduction into interstate commerce of an unapproved drug)

ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions