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3 Parkinsons disease (PD) is the second most common neurodegenerative disorder affecting about 15% of the general population

In attempts to produce erythrocytes with a lower oxygen affinity to be administered in a patient in need when normal blood flow is impaired, inositol hexaphosphate (InsP6)-loaded erythrocytes were prepared and investigated (Teisseire et al., 1985)

The ACE/Ang II/AT1R classical pathway aggravates depression and anxiety by activating AT1R, while the non-classical pathway exerts anxiety/antidepressant effects by activating MasR

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