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It's why batteries get warm when in use

No prospective studies have been conducted in humans in controlled circumstances to demonstrate whether CYP450 polymorphisms lead to an increase or a decrease in paracetamol oxidation nor have there been studies demonstrating that CYP450 polymorphisms in humans increase or decrease the risk of paracetamol toxicity before or after an overdose

10.1016/j.phrs.2020.105083 [DOI] [PubMed] [Google Scholar] Kim S., Moon M., Park S

Thats why the conversation about its emotional impact is just as important as the discussion around its physical results

Science 288 , 23792381 (2000)