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In practice, stacking multiplies uncertainty: more compounds more chances of impurity/contamination more pathways affected more interaction risk more variables harder to know what helped (or harmed) If you take only one clinical principle from this article: the more experimental the stack, the more conservative your risk posture should be

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Because Wegovy, Saxenda, and some uses of Zepbound are labeled and prescribed for weight management or obesity, they fall under this exclusion

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