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Local anaesthetic, analgesia or breaks in treatment may be required

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STAT3 Signaling Pathway Signal transduction and transcription activator 3 (STAT3) can be activated by phosphorylation of extracellular signaling molecules and then enter the nucleus, bind to DNA, regulate the transcription of ferroptosis-related genes (e.g., GPX4, superoxide dismutase, etc.) and affect the production of ROS, thereby inhibiting ferroptosis [137]

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Signal Transduct Target Ther 6:49

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Burrell et al., 2016)

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