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In this setting, SGAs should therefore be viewed not as a risk-mitigating alternative to tracheal intubation but as devices whose elective safety profile depends on low-regurgitation assumptions that are unlikely to hold

For example, a recent study indicated that unlike in mouse islets where tirzepatide stimulates insulin secretion predominantly through the GLP-1R, the therapeutic effects of tirzepatide on human beta and alpha cells require engagement of both the GLP-1R and the GIPR, and in addition, tirzepatide increased glucagon secretion in isolated islets [207]

doi: 10.1111/dom.14843, 53 GibbonsC.BlundellJ.Tetens HoffS.DahlK.BauerR.BaekdalT

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The GIP receptor component strengthens insulin secretion and improves glucose metabolism, particularly important for patients with type 2 diabetes or prediabetes