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There are some steps you can take to reduce the appearance of these dark spots: Avoid scratching or picking Physical contact like picking at your bumps, scratching them and scrubbing them can lead to inflammation and irritation of your KP, increasing your risk of pigmentation

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Furthermore, SSTRs, particularly SSTR5, are highly expressed in intestinal L-cells that secrete glucagon-like peptide-1 (GLP-1) and K-cells that secrete glucose-dependent insulinotropic polypeptide (GIP)

the Key Project of the National Natural Science Foundation of China (U20A20354)