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We know that GABA and glutamate are key chemicals in the brain for plasticity and learning and so these children should have an opportunity for better quality of life and wellbeing." The team say the discovery that bumetanide changes the relative of concentrations of GABA to glutamate could provide a useful biomarker a tell-tale biological measure of how effective a treatment is

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Regulation of human dihydrofolate reductase activity and expression