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Wide-pore columns (300 angstrom pore C18 or C4, 2.1 or 4.6 mm ID) with peptide-optimized mobile phases (aqueous TFA or formic acid/acetonitrile gradients) are required

doi: 10.1016/j.jacc.2006.11.039 64

Key highlights: TRIUMPH-2 (Adults with obesity/overweight + Type 2 Diabetes) * Up to 20.8% mean weight loss (49.6 lbs / 22.5 kg) at 80 weeks

Some require only weekly use by injection, and a few are oral formulations

In a portal hypertension model, FMT enriched butyrate-producing bacteria, and the resulting butyrate activated the PI3K/Akt/eNOS signaling pathway by inhibiting HDAC3 activity in liver sinusoidal endothelial cells, increasing nitric oxide production and thereby reducing intrahepatic vascular resistance