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High-fat diet (HFD) feeding and obesity induced a shift in the microbiota from Bacteroides to Firmicutes in mice, and the abundance of certain Firmicutes species was positively correlated with energy intake and plasma C-reactive protein (CRP) levels ( Studies demonstrate that gut microbiota and their metabolites influence the brain through direct vagal signaling or indirect immune-neuroendocrine pathways (73)

Worse still, their accumulation in tissues contributes to chronic inflammation, degenerative diseases and general ageing of the body

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