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A high-fiber diet can make stool softer and bulkier so that it passes easily

Rather than disrupting the binding pocket directly, the biotin modification extends through a solvent accessible pore formed at this loop (amino acids 5963) from the protein surface distal to the binding pocket (Supplementary Fig

Another concern is ease of access

Along with weight loss, the treatment helped improve blood sugar control and lowered the risk of major cardiovascular events

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