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for example, 3 kg weight reduction leads to a marginal improvement in LDL-C and mean reduction in triglycerides of 15 mg/dL, while weight loss of 58 kg, lowers LDL-C on average by 5 mg/dL and increases HDL-C by 3 mg/dL

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GLP-1 also delays gastric emptying by inhibiting gastrointestinal (gut) motility via the ileal brake 4 , a feedback mechanism activated by unabsorbed dietary components in the ileum (portion of the small intestine)

Therefore, combining SGLT2 inhibitors with drugs acting via different mechanisms might be the most effective approach for major weight loss and address counter-regulatory mechanisms that maintain body weight [41]

Even two sessions per week of moderate resistance training can make a meaningful difference in body composition outcomes