Pretreatment with losartan significantly improves FST performance and prevents LPS-induced anhedonia and anxiety-like behaviors in addition to preventing LPS-induced higher levels of the pro-inflammatory cytokine (TNF, IL-1, and IL-6) (99, 116)
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However, a handful of human studies suggest that some peptides might be worth exploring further in larger, more rigorous studies
Production of antimicrobial peptides and reactive oxygen species (ROS): When mast cells degranulate, they release molecules such as antimicrobial peptides and reactive oxygen species that damage and neutralize invading microbes