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PRECAUTIONS: Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord

[2] [20] [72] [73] Neurological abnormalities in fetal alcohol spectrum disorders may present as either hard neurological signs, such as epilepsy or other seizure disorders, or as soft neurological signs

Concomitant administration of these agents can produce a decrease in the serum concentration of the affected drug which may translate to reduced therapeutic efficacy