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Zeros in the data were converted to missing values (NAs) to improve heritability estimates

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ROS, also as a second messenger, can activate tyrosine kinases and MAPK which promote cell development (81), and the protein kinase-B (Akt)/mTOR signaling pathway which promotes cell growth of gastric cancer (82)

By activating both GIP and GLP-1 receptors, Tirzepatide influences multiple pathways that affect metabolism, helping improve energy balance and body composition