Accordingly, we encourage the adoption of GLP-1RA plus SGLT2i combination therapy in patients with T2DM and established atherosclerotic cardiovascular disease (ASCVD) or multiple risk factors for ASCVD (i.e., age 55 years, overweight/obesity, dyslipidemia, hypertension, current tobacco use, left ventricular hypertrophy, and/or proteinuria)
Hoke, T
While originally developed to treat type 2 diabetes, these drugs have gained widespread use for weight loss, often achieving reductions of 15-21% in body weight when paired with proper nutrition and exercise
In a cohort of 74 patients with biopsy-proven NASH, 48-week treatment with rosiglitazone combined with diet and physical activity, compared to diet and exercise alone, was shown to significantly ameliorate NAS, steatosis, and ballooning, but no effect was detected on fibrosis [45]
Add sterile water, bacteriostatic water, or PBS slowly down the vial wall and swirl gently do not shake