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When the cell senses oxidative stress, Nrf2 responds by translocating from the cytoplasm to the nucleus, where it binds to the antioxidant-response elements located in the promoter regions of genes responsible for antioxidant production [68, 69]

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This outcome would have little consequence to the success of the individual in terms of selective advantage

Similar results were seen in patients who had originally taken Wegovy, with those taking a placebo pill regaining 62% of their lost body weight, compared to 21% weight regain in those taking orforglipron