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Protocol 1: moderate weight loss (10-15% body weight) Goal: Steady, sustainable weight loss with minimal side effects Tirzepatide approach: Standard escalation to 5-7.5 mg Hold at the dose where you achieve consistent weekly loss of 0.5-1% body weight Expected timeline: 24-36 weeks to target Likely maintenance dose: 5-7.5 mg Retatrutide approach: Standard escalation to 4 mg 4 mg delivered 12.9% weight loss at 24 weeks in trials Hold at 4 mg if achieving target rate Expected timeline: 20-30 weeks to target For moderate goals, both compounds work well at their lower dose ranges

doi: 10.1038/nrm1960 57 AkabasMH

doi: 10.1016/j.bbi.2019.06.039 54 WangYBiSLiXZhongYQiD

Delphinidin targets the Nuclear Factor-kappa B (NF-B) pathway by downregulating IKK, thereby inhibiting IB phosphorylation and NF-B p65 nuclear translocation, leading to G2/M cell cycle arrest (Yun et al., 2009

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