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Emerging research has also highlighted the critical role of epigenetic and post-transcriptional regulation, particularly through microRNAs (miRNAs), which serve as key modulators of immune responses and microbial interactions in IBD, influencing not only immune modulation but also iron metabolism, oxidative stress, and epithelial integrity, all of which are critical to ferroptosis in IBD (94, 95)

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Clinical trials of semaglutide and tirzepatide have not identified injection site pain as a major adverse event leading to treatment discontinuation