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In addition, TMAO induces several inflammatory pathways, which cause the activation of pro-inflammatory cytokines such as IL-6 and TNF- which causes chronic inflammation thereby causing plaque formation and plaque rupture leading to cardiovascular disease [71]

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Indeed, differentially regulated transcripts belonging to GO biological processes involved in stroma deposition and immune response in SEMA, HFD and LFD mice bearing KPC organoids clearly showed the therapeutic potential of this anti-dysmetabolic treatment in PDAC (Suppl