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If a patient on semaglutide 2.4 mg (Wegovy) has not met that threshold after 16 weeks, switching to tirzepatide is a reasonable next step supported by that guideline framework

Lopez Bastida J, Oliva J, Antonanzas F, Garcia-Altes A, Gisbert R, Mar J, Puig-Junoy J

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In addition, exendin-4 injection enhanced calcium signals in DMH GLP-1R neurons in the pre-ingestive stage, and exendin-4-induced pre-ingestive satiation was mitigated by optogenetic inhibition of DMH GLP-1R neurons

doi: 10.1074/jbc.273.25.15830 49 KongEPengSChandraGSarkarCZhangZBaghMBet al