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There was no escape option within the maze, and mice were allowed to freely explore it for five minutes while the path they took through the three arms was tracked by recording their entries into each arm

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We found that glutathione and thioredoxin, the major thiol antioxidants, and glutathione and thioredoxin reductases, the enzymes responsible for maintaining them in a reduced state, fell substantially in rodent bone marrow after ovariectomy and were rapidly normalized by exogenous 17- estradiol

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