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The National Institute on Drug Abuse (NIDA) is currently funding randomized clinical studies to assess whether GLP-1 medications could help treat opioid and stimulant use disorders as well

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In animal models, preclinical work has also documented antinociceptive effects (attributed to indirect Met-enkephalin release [7]), antioxidant enzyme stimulation [11], and inhibition of hypothalamic somatostatin secretion [8]

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