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The groups that received the riboflavin-fortified salt had lower rates of esophageal cancer.[ref] Inflammatory Bowel Disease (IBD): In patients with Crohns disease, riboflavin (100mg/day) decreased inflammatory markers significantly in three weeks.[ref] Related article: IBD and Genetic Connections Inflammation: A randomized, placebo-controlled trial of supplemental riboflavin found that it reduced inflammation based on a lower CRP level.[ref] Related article : Inflammation and chronic disease Gut microbiome interactions with riboflavin: Certain gut microbes can produce riboflavin, part of which is then absorbed into the body

In the future, rather than look for additional global markers of astrogliosis, it will likely be more useful to look for molecules upregulated by astrocytes in specific contexts and that are associated with specific functions or effects of astrogliosis

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Extended interruptions of multiple days warrant protocol reassessment

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