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Tracy Norfleet, MD, FACP, advises: "Injection site may be infected if you notice redness, warmth, or tenderness or swelling in the area, and it keeps getting worse or lasts more than 1 to 2 days." Here are specific signs that should prompt you to consult your doctor: Pus or discharge coming from the injection site Warmth spreading beyond the immediate area Red streaking extending outward from the injection site Redness or swelling larger than 2 inches in diameter Hardened lumps that dont go away, suggesting a possible infection Severe pain that disrupts your daily activities Reactions lasting more than a week Unusual skin discoloration Fever accompanied by chills New lumps or swelling in your neck, especially with hoarseness or difficulty swallowing If any of these symptoms appear, dont delay contacting your healthcare provider

Klein H, et al