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Elevated IGF-1 levels have been linked to enhanced chondrocyte proliferation, cartilage matrix production, and osteoblast differentiationmechanisms that support fracture healing and joint preservation

Insulin resistance triggers excess androgen production, leading to issues like irregular cycles, fertility challenges, weight gain, and a higher risk of diabetes

While oral bioavailability is lower than subcutaneous administration, these studies established that even high oral doses maintained excellent safety profiles, though higher doses (54 mg) were associated with increased gastrointestinal discomfort

VDAC, a multi-functional mitochondrial protein regulating cell life and death

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