So as one problem, a shortage, is solved, another arises: Cheaper copycat drugs fall into an even grayer area of legality
Between June and July 2025, when the formulary change was implemented, switching from AOM tirzepatide increased, while patients with an active supply of AOM semaglutide showed stable or even slightly reduced switching during the same period, consistent with its designation as the preferred option
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6.4 Emerging macrocyclic peptides: a new generation of oral candidates Recent advances in macrocyclic peptide design have produced a new generation of oral candidates that warrant attention
The authors noted, ...semaglutide was superior to placebo for MACE reduction at all levels of baseline weight or waist circumference from early in the study. Here is a gift link to a New York Times article about this study