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Any central effect is not well-characterized yet, but it is a subject of ongoing research

Furthermore, 24-h ambulatory monitoring indicated that setmelanotide did not induce increases in heart rate or blood pressure, pointing to favorable cardiovascular safety [55]

This mechanism of action prevents the dimerization of these two proteins and blocks the binding of NRG1 to HER3, in turn reducing cell proliferation and promoting the immune systems cancer-killing activity

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