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The two major limitations of this trial are that the treatment duration was only for 28 d and the subjects were under generally excellent metabolic control

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Small molecule SARM1 inhibitors recapitulate the SARM1-/- phenotype and allow recovery of a metastable pool of axons fated to degenerate

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We conclude, that oxidative metabolism plays an important role in pathogenesis of WRS-induced gastric lesions