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Common Side Effects The most commonly reported adverse events are gastrointestinal in nature: Nausea (approximately 20-44% of participants) Diarrhea (approximately 30%) Vomiting (approximately 24%) These symptoms are typically mild to moderate in severity, tend to occur most frequently during dose escalation, and generally diminish over time as tolerance develops

Providers typically evaluate the trend over multiple weeks before making any dosing changes

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In SURPASS-2, tirzepatide caused diarrhea in 13-16% of participants, while semaglutide 1 mg caused it in 12%