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This dual action is why people often report that foods they once cravedincluding pizzafeel less appealing or that a single slice now feels like enough, whereas they previously ate three or four

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This imbalance is believed to be manifested in most brain regions, including the amygdala, cortex, and hippocampus, and plays a central role in several pathological conditions, such as Fragile X Syndrome (FXS), epilepsy, and ASD

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We found that if we silence the PBN during naloxone-precipitated withdrawal, we can reduce certain debilitating symptoms associated with opioid withdrawal