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En un estudio de 13 semanas de duracin realizado con ratones (empleando dosis de 0, 7,5, 15, 50, 275 750 mg/kg en el alimento), se observ mayor incidencia de hiperplasia e hiperkeratosis de las clulas epiteliales escamosas del preestmago en el caso de los machos y las hembras cuando se emplearon posologas de 50 mg/kg y superiores

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V., Chang, B., Imamura, M., Poungvarin, N