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Sirtuins (SIRT1SIRT7) are NAD+-dependent enzymes that deacetylate proteins involved in DNA repair, mitochondrial biogenesis, inflammation suppression, and circadian rhythm regulation

The question is whether they can afford not to

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Glutathione-S-transferase catalyzes the conjugation of NAPQI with GSH, forming APAP-GSH adducts, 9,10 which are further metabolized into nontoxic thiolate and cysteine molecules, including adducts of cysteamide, glycine/cysteine, and N-acetyl-L-cysteine

While individual biology varies, the trajectory of repair follows a consistent path