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This highlights the complexity of GPCR activation, where downstream signalling is influenced by the interplay of multiple transducers that can interact with activated receptors (pleiotropic coupling), and can also be influenced by different trafficking profiles that alter the location of the receptor in the cell

Cyclic positional and B-factor refinement with strict NCS constraints was then performed with CNS, and models were improved with COOT 39,40

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Generic Crestor, a cholesterol-lowering med, costs $151 a month at the local CVS, a steep discount from the brand-name pill, which runs $329