humanized glp-1 receptor knock-in mouse Reagents and models for detecting endogenous GLP1R and GIPR Distinct Neural Sites of GLP-1R

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Although the exact mechanisms by which the coordinated actions of GLP-1 receptor agonism and NMDA receptor antagonism correct metabolic diseases await further elucidation, the extensive alterations in transcriptomic and proteomic responses within the hypothalamus, linked to glutamatergic signalling and synaptic plasticity, imply that the conjugate might elicit neurostructural changes in GLP-1-receptor-expressing neurons

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Rubino D.M., Greenway F.L., Khalid U., et al

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