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This condition has been observed in persons who drink moonshine that was distilled in automobile radiators containing a high lead concentration

The solution remains clear but the peptide is pharmacologically inactive

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[13] [19] Specifically, the function of GSTs in this role is twofold: to bind both the substrate at the enzyme's hydrophobic H -site and GSH at the adjacent, hydrophilic G-site, which together form the active site of the enzyme