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For instance, the expression of ChR2 in Purkinje cells, which can be induced using transgenic mutant mice, by in utero electroporation or by viral injections [107], allows precise control over action potential firing in their downstream target, the cerebellar nuclei [108] and thereby over cerebellar-evoked excitation or inhibition in the thalamus

However, it is crucial to understand that humans have significantly fewer GLP-1 receptors on thyroid C-cells compared to rodents, and extensive post-marketing surveillance and clinical trial data have not demonstrated an increased risk of medullary thyroid carcinoma in human populations