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gingivalis synergistically regulates three core pathways via the TLR4/NF-B signaling pathway: (1) iron metabolism imbalance (upregulation of TFRC and NCOA4 expression leading to intracellular iron overload), (2) lipid metabolism reprogramming (enhanced ACSL4 and LPCAT3 activity promoting polyunsaturated fatty acid phospholipid accumulation), (3) antioxidant defense collapse (downregulation of SLC7A11 and GPX4 triggering glutathione depletion and impaired lipid peroxide clearance)

Heart 2012;98:408413

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Oral semaglutide (Rybelsus) proved GLP-1 benefits are achievable in tablet form

Mar 2015;71(3):263-70