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In this context, low expression of these two genes would lead not only to decreased glutathione synthesis by the GSS enzyme, but also to decreased glutathione conjugation by the GSTA1 enzyme 16,45

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Activation of S1PR2 by specific BAs, particularly conjugated BAs such as taurocholic acid (TCA), stimulates the RhoA/ROCK1 signaling axis in macrophages, facilitating M1 polarization and NLRP3 inflammasome activation