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Stephen Bent, a professor of medicine, epidemiology, and biostatistics at the University of California, San Francisco, told Healthline

Int J Biochem Cell Biol (2007) 39:4484

doi: 10.1159/000187623

Nevertheless, increased local cortisol availability in WAT may exert effects similar to those observed in Cushing syndrome (CS), including the induction of IR and exacerbation of obesity [151], despite stable circulating glucocorticoid levels (in contrast to CS) [152]

Hypoglycemia with Concomitant Use of Insulin or Insulin Secretagogues Inform patients that the incidence of hypoglycemia may increase when XIGDUO XR is added to an insulin secretagogue (e.g., sulfonylurea) and/or insulin