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In comparison, anti-CXCL10 antibody might interfere with other regular tumor therapies as CXCL10 within tumor tissue binds CXCR3 to exert antitumor effect
Favourable hypotensive effect after standardised tomato extract treatment in hypertensive subjects at high cardiovascular risk: a randomised controlled trial
m 6 A methylation modification regulates key enzymes in gemcitabine metabolism through the dynamic balance of METTL3 (methyltransferase-like 3) and FTO (Fat mass and obesity-associated protein, demethylase) ( 6 A modification enhances the mRNA stability of deoxycytidine kinase (dCK) to promote gemcitabine activation ( 6 A modification, but may also reduce dCK activity ( 6 A and lncRNA have cross-regulation (such as METTL3 modification of MALAT1 to enhance its stability, and FTO regulates NEAT1 function) ( Figure 6 illustrates the epigenetic and post-transcriptional regulatory network contributing to gemcitabine resistance through modulation of RRM2 and dCK expression
Statistics & reproducibility The statistical analyses of the data were conducted using GraphPad Prism and MS Excel using the tests indicated in the legends of the individual figure panels
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